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Article

Weak linkage at 4p16 to predisposition for human neuroblastoma.

Oncogene - 28 Nov 2002

Perri Patrizia, Longo Luca, Cusano Roberto, McConville Carmel M, Rees Sally A, Devoto Marcella, Conte Massimo, Ferrara Giovanni Battista, Seri Marco, Romeo Giovanni, Tonini Gian Paolo

Abstract excerpt

The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic deletions have been demonstrated at other chromosomal intervals. Since loss of heterozygosity (LOH) at distal 4p has been observed in about 20-29% of neuroblastomas, we have evaluated deletions in 41 Italian NB samples by LOH analysis at loci mapping to 4p as...

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Identifiers

PMID: 12447700
DOI: 10.1038/sj.onc.1206009

Genes

MYCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Weak linkage at 4p16 to predisposition for human neuroblastoma.PMID 12447700Read ↗

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Localization of a hereditary neuroblastoma predisposition gene to 16p12-p13.Semantic proximity Read ↗

Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus.Semantic proximity Read ↗

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