There may be two tumor suppressor genes on chromosome arm 1p closely associated with biologically distinct subtypes of neuroblastoma.

doi:10.1002/gcc.2870100106

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Article

There may be two tumor suppressor genes on chromosome arm 1p closely associated with biologically distinct subtypes of neuroblastoma.

Genes, chromosomes & cancer - 1 May 1994

Takeda O, Homma C, Maseki N, Sakurai M, Kanda N, Schwab M, Nakamura Y, Kaneko Y

Abstract excerpt

We studied loss of heterozygosity (LOH) on chromosome arm 1p in 108 neuroblastomas using 14 polymorphic DNA markers. One-hundred and four tumors with one or more informative loci; 21 (20%) of the 104 tumors showed LOH on 1p, and were classified into three groups on the basis of interstitial or te...

Topics

Alleles
Child
Child, Preschool
Chromosome Deletion
Chromosomes, Human, Pair 1
Gene Amplification
Genes, Tumor Suppressor
Genes, myc
Heterozygote
Humans
Infant
Neuroblastoma
Ploidies
Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 7519871
DOI: 10.1002/gcc.2870100106

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7519871-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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