Article
Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification.
Nature genetics - 1 Jun 1993
Caron H, van Sluis P, van Hoeve M, de Kraker J, Bras J, Slater R, Mannens M, Voûte P A, Westerveld A, Versteeg R
Abstract excerpt
Neuroblastomas frequently have deletions of chromosome 1p and amplification of the N-myc oncogene. We analysed 53 neuroblastomas for the N-myc copy number, loss of heterozygosity (LOH) of chromosome 1p36 and the parental origin of the lost alleles. Allelic loss of 1p36 was found in 15 tumours. Al...
Topics
- Adult
- Alleles
- Child, Preschool
- Chromosomes, Human, Pair 1
- DNA, Neoplasm
- Female
- Gene Amplification
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, myc
- Genetic Markers
- Humans
- In Vitro Techniques
- Infant