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Article

Multilocus loss of heterozygosity allelotypes identify a genetic pathway associated with progression from low to high stage disease in neuroblastoma.

European journal of cancer (Oxford, England : 1990) - 1 Aug 2006

Chughtai Shaheen A, Genus Tracey, Ramani Pramila, Dyer Sara, Powell Judy E, McMullan Dominic, Davison Val, McConville Carmel M

Abstract excerpt

Neuroblastoma is a heterogeneous tumour with a variety of clinical phenotypes, ranging from a localised tumour with excellent outcome (stage 1) to a metastatic, usually fatal malignancy (stage 4). In order to investigate the genetic relationship between these tumour subtypes, a loss of heterozygosity (LOH) analysis was carried out. Composite LOH allelotypes incorporating data from 96 loci on 5 chromosomes (1p,...

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Source

Identifiers

PMID: 16872824
DOI: 10.1016/j.ejca.2006.03.016

Genes

MYCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multilocus loss of heterozygosity allelotypes identify a genetic pathway associated with progression from low to high stage disease in neuroblastoma.PMID 16872824Read ↗

Clinical categories of neuroblastoma are associated with different patterns of loss of heterozygosity on chromosome arm 1p.Semantic proximity Read ↗

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