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Article

Promoter region polymorphism in the human TNF-alpha gene is not associated with lichen sclerosus.

Experimental dermatology - 1 Aug 1996

Clay F E, Cork M J, Wilson A G, Crane A M, Lewis F, Harrington C I, Duff G W

Abstract excerpt

The pathogenesis of lichen sclerosus remains unknown. However, it has been frequently associated clinically with autoimmunity. The MHC haplotype A1, B8, DR3 is associated with many autoimmune conditions and has also been associated with the uncommon allele of the tumour necrosis factor (TNF-alpha) promoter polymorphism. This allele is also associated with higher production of TNF in vivo and in vitro, and thus it...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8889470
DOI: 10.1111/j.1600-0625.1996.tb00121.x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Promoter region polymorphism in the human TNF-alpha gene is not associated with lichen sclerosus.PMID 8889470Read ↗

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