Article
A - 308 promoter polymorphism of tumor necrosis factor alpha gene does not associate with the susceptibility to psoriasis vulgaris. No difference either between psoriasis type I and type II patients.
Acta dermatovenerologica Alpina, Pannonica, et Adriatica - 1 Sept 2006
Baran Wojciech, Szepietowski Jacek C, Mazur Grzegorz, Baran Eugeniusz
Abstract excerpt
BACKGROUND: Genes encoded within the MHC complex on chromosome 6 are thought to play an important role in the pathogenesis of psoriasis. A potential candidate is tumor necrosis factor alpha (TNF-alpha) gene. Psoriasis features an increased activity of the proinflammatory cytokine TNF-alpha in affected lesions. TNF-alpha promoter region contains several polymorphisms, including G/A transition at position -308,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.