Article
Lack of association with TNF-alpha-308 promoter polymorphism in patients with vitiligo.
Archives of dermatological research - 1 Jun 2006
Yazici Ayca Cordan, Erdal M Emin, Kaya Tamer Irfan, Ikizoglu Guliz, Savasoglu Kaan, Camdeviren Handan, Tursen Umit
Abstract excerpt
Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in which tumor necrosis factor-alpha (TNF-alpha), a paracrine inhibitor of melanocytes, is especially...
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