Article
Tumor necrosis factor alpha-308 gene variants in relation to major histocompatibility complex alleles and Felty's syndrome.
Human immunology - 1 Dec 1994
Brinkman B M, Giphart M J, Verhoef A, Kaijzel E L, Naipal A M, Daha M R, Breedveld F C, Verweij C L
Abstract excerpt
The location of the human TNF genes within the MHC complex has prompted much speculation about the role of TNF alleles in the etiology of MHC-associated autoimmune diseases. On sequencing the 5' regulatory region of the human TNFA gene a G (TNFA-308G) to A (TNFA-308A) transition polymorphism at position -308 was discovered. We have developed a simple PCR assay to facilitate the screening of the -308 polymorphism...
Topics
- Alleles
- Base Sequence
- Felty Syndrome
- Humans
- Lymphotoxin-alpha
- Major Histocompatibility Complex
- Molecular Sequence Data
- Tumor Necrosis Factor-alpha