Article
Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997
Sowell M O, Ye C, Ricupero D A, Hansen S, Quinn S J, Vassilev P M, Mortensen R M
Abstract excerpt
Cardiac muscarinic receptors activate an inwardly rectifying K+ channel, IK+Ach, via pertussis toxin (PT)-sensitive heterotrimeric G proteins (in heart Gi2, Gi3, or Go). We have used embryonic stem cell (ES cell)-derived cardiocytes with targeted inactivations of specific PT-sensitive alpha subun...
Topics
- Carbachol
- Cell Line
- GTP-Binding Proteins
- Mutation
- Myocardium
- Potassium Channel Blockers
- Potassium Channels
- Receptors, Purinergic P1