Article
Linkage analysis using platelet-activating factor Ca2+ response in transformed lymphoblasts.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 1997
Brzustowicz L M, Gardner J P, Hopp L, Jeanclos E, Ott J, Yang X Y, Fekete Z, Aviv A
Abstract excerpt
Epstein-Barr virus-transformed lymphoblasts from patients with essential hypertension demonstrate enhanced G protein-mediated cytosolic free calcium ([Ca2+]i) response to platelet-activating factor (PAF). To map genes responsible for variation in G protein-coupled signaling, we used this cellular phenotype for a linkage study of transformed cell lines from the Centre d'Etude du Polymorphisme Humain (CEPH)...
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