Article
Association of a human G-protein beta3 subunit variant with hypertension.
Nature genetics - 1 Jan 1998
Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma A M, Ritz E, Wichmann H E, Jakobs K H, Horsthemke B
Abstract excerpt
Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor for cardiovascular events such as stroke and myocardial infarction. Previous studies demonstrated an enhanced signal transduction via pertussis toxin-sensitive G proteins in lymphoblasts and fibroblast...
Topics
- Alleles
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Cell Line
- GTP-Binding Proteins
- Genetic Variation
- Guanosine 5'-O-(3-Thiotriphosphate)
- Humans
- Hypertension
- Intercellular Signaling Peptides and Proteins
- Molecular Sequence Data
- Peptides
- Recombinant Fusion Proteins
- Spodoptera