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Article

Association of a human G-protein beta3 subunit variant with hypertension.

Nature genetics - 1 Jan 1998

Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma A M, Ritz E, Wichmann H E, Jakobs K H, Horsthemke B

Abstract excerpt

Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor for cardiovascular events such as stroke and myocardial infarction. Previous studies demonstrated an enhanced signal transduction via pertussis toxin-sensitive G proteins in lymphoblasts and fibroblasts from selected patients with essential hypertension. We have detected a novel polymorphism (C825T) in exon 10 of the...

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Source

Identifiers

PMID: 9425898
DOI: 10.1038/ng0198-45

Genes

GNB3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Association of a human G-protein beta3 subunit variant with hypertension.PMID 9425898Read ↗

G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension.Semantic proximity Read ↗

G-protein beta3 subunit 825T allele and hypertension.Semantic proximity Read ↗

G protein polymorphisms in hypertension, atherosclerosis, and diabetes.Semantic proximity Read ↗

The genetic variant C825T of the beta 3 subunit of G protein is associated with hypertension in a Portuguese population.Semantic proximity Read ↗

G protein beta3 subunit variant: tendency of increasing susceptibility to hypertension in Japanese.Semantic proximity Read ↗

G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review.Semantic proximity Read ↗

The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls.Semantic proximity Read ↗

The 825C/T polymorphism of the G-protein subunit beta3 is not related to hypertension.Semantic proximity Read ↗

G protein beta3 subunit gene polymorphism in Turkish hypertensives.Semantic proximity Read ↗

G-Protein beta3 subunit C825T variant and ambulatory blood pressure in essential hypertension.Semantic proximity Read ↗

A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels.Semantic proximity Read ↗

G protein beta 3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy.Semantic proximity Read ↗

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