Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene polymorphism at position -308 of the tumor-necrosis-factor-alpha (TNF-alpha) in multiple sclerosis and it's influence on the regulation of TNF-alpha production.

Neuroscience letters - 6 Sept 1996

Braun N, Michel U, Ernst B P, Metzner R, Bitsch A, Weber F, Rieckmann P

Abstract excerpt

Tumor-necrosis-factor alpha (TNF-alpha) is a major mediator of the inflammatory immune response and may play an important role in the pathogenesis and progression of Multiple Sclerosis (MS). Increased TNF-alpha levels of cerebrospinal fluid (CSF) and peripheral blood were found in patients with chronic progressive MS and patients with acute relapses, but not in the stable form of the disease. Considering the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Point Mutation

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 8887999

Genes

TNF
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene polymorphism at position -308 of the tumor-necrosis-factor-alpha (TNF-alpha) in multiple sclerosis and it's influence on the regulation of TNF-alpha production.PMID 8887999Read ↗

Gene polymorphism at position -308 of the tumor necrosis factor alpha promotor is not associated with disease progression in multiple sclerosis patients.Semantic proximity Read ↗

Tumour necrosis factor alpha gene (TNF-alpha) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis.Semantic proximity Read ↗

-308 G > A of TNF-α gene promoter decreases the risk of multiple sclerosis: a meta-analysis.Semantic proximity Read ↗

TNF-alpha promoter polymorphisms in multiple sclerosis: no association with -308 and -238 alleles, but the -857 alleles in associated with the disease in Turkish patients.Semantic proximity Read ↗

TNF-alpha polymorphisms in multiple sclerosis: no association with -238 and -308 promoter alleles, but the microsatellite allele a11 is associated with the disease in French patients.Semantic proximity Read ↗

Association of polymorphism -308G/A in tumor necrosis factor-alpha gene (TNF-α) and TNF-α serum levels in patients with relapsing-remitting multiple sclerosis.Semantic proximity Read ↗

Decreased frequency of the tumor necrosis factor alpha -308 allele in Serbian patients with multiple sclerosis.Semantic proximity Read ↗

Tumor necrosis factor-alpha-308 gene polymorphism in Croatian and Slovenian multiple sclerosis patients.Semantic proximity Read ↗

Tumor necrosis factor alpha gene -376 polymorphism and susceptibility to multiple sclerosis: an Egyptian study.Semantic proximity Read ↗

Genetic variants in the tumor necrosis factor receptor II gene in patients with multiple sclerosis.Semantic proximity Read ↗

The polymorphisms of the TNF-α gene in multiple sclerosis?--a meta-analysis.Semantic proximity Read ↗

TNF-α -308 G/A and -238 G/A promoter polymorphisms and sporadic Parkinson's disease in an Italian cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.