The polymorphisms of the TNF-α gene in multiple sclerosis?--a meta-analysis.

doi:10.1007/s11033-010-0533-0

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Article

The polymorphisms of the TNF-α gene in multiple sclerosis?--a meta-analysis.

Molecular biology reports - 1 Aug 2011

Xu Lidan, Yuan Weiguang, Sun Haiming, Zhang Xuelong, Jia Xueyuan, Shen Chao, Zhao Yanling, Sun Donglin, Yu Yang, Jin Yan, Fu Songbin

Abstract excerpt

The association between multiple sclerosis (MS) and tumor necrosis factor-alpha gene (TNF-α) polymorphisms has been analyzed in several studies, but conflicting results have been reported. The main purpose of this study was to integrate previous findings and explore whether the three single nucleotide polymorphisms (SNPs; -238G/A, -308G/A, and -376G/A) of TNF-α are associated with susceptibility to MS. A total of...

Topics

Adult
Female
Genetic Heterogeneity
Humans
Male
Models, Genetic
Multiple Sclerosis
Odds Ratio
Polymorphism, Single Nucleotide
Publication Bias
Tumor Necrosis Factor-alpha

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Open in PubMed

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PMID: 21136171
DOI: 10.1007/s11033-010-0533-0

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