Article
-308 G > A of TNF-α gene promoter decreases the risk of multiple sclerosis: a meta-analysis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jun 2011
Yang Yan, Sun Rulin, Yang Heng, Zheng Fang, Gong Feili
Abstract excerpt
BACKGROUND: Environmental and genetic factors are thought to be involved in the pathogenesis of multiple sclerosis (MS). Polymorphisms of tumor necrosis factor (TNF)-α -308 were implicated in MS risk in several case-control association studies. However, the studies have shown inconsistent results. OBJECTIVES: To address the association of G/A polymorphisms of TNF-α -308 with MS risk by meta-analysis. METHODS:...
Topics
- Case-Control Studies
- Chi-Square Distribution
- Gene Frequency
- Genetic Predisposition to Disease
- Heterozygote
- Homozygote
- Humans
- Linear Models
- Multiple Sclerosis
- Odds Ratio
- Phenotype