TNF-alpha polymorphisms in multiple sclerosis: no association with -238 and -308 promoter alleles, but the microsatellite allele a11 is associated with the disease in French patients.

Abstract excerpt

Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, is believed to play an important role in multiple sclerosis (MS) pathogenesis. The objective of this study was to determine whether sequence variation in the TNF-alpha gene is associated with MS. Bi-allelic polymorphisms in the TNF-alpha promoter region (TNF-alpha -238 and -308) and microsatellite TNF-alpha were previously reported. We...

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