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Article

Gene polymorphism at position -308 of the tumor necrosis factor alpha promotor is not associated with disease progression in multiple sclerosis patients.

Journal of neurology - 1 Oct 1999

Mäurer M, Kruse N, Giess R, Kyriallis K, Toyka K V, Rieckmann P

Abstract excerpt

Tumor necrosis factor-alpha (TNFalpha) is a pluripotent proinflammatory cytokine and is thought to play an important role in the inflammatory process of multiple sclerosis (MS). A G-->A transition in the TNFalpha promotor at position -308 (TNF2 allele) has been shown to be associated with increas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10552245
DOI: 10.1007/s004150050489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10552245-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Gene polymorphism at position -308 of the tumor necrosis factor alpha promotor is not associated with disease progression in multiple sclerosis patients.PMID 10552245Read ↗

Tumor necrosis factor-alpha-308 gene polymorphism in Croatian and Slovenian multiple sclerosis patients.Semantic proximity Read ↗

Gene polymorphism at position -308 of the tumor-necrosis-factor-alpha (TNF-alpha) in multiple sclerosis and it's influence on the regulation of TNF-alpha production.Semantic proximity Read ↗

Decreased frequency of the tumor necrosis factor alpha -308 allele in Serbian patients with multiple sclerosis.Semantic proximity Read ↗

A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis.Semantic proximity Read ↗

Tumor necrosis factor alpha-308 alleles in multiple sclerosis and optic neuritis.Semantic proximity Read ↗

Tumour necrosis factor alpha gene (TNF-alpha) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis.Semantic proximity Read ↗

The -308 G/A polymorphism in the tumor necrosis factor-α gene is not associated with development and progression of rheumatoid arthritis in Argentinean patients.Semantic proximity Read ↗

TNF-alpha polymorphisms in multiple sclerosis: no association with -238 and -308 promoter alleles, but the microsatellite allele a11 is associated with the disease in French patients.Semantic proximity Read ↗

Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?Semantic proximity Read ↗

Genetic association studies of tumour necrosis factor alpha and beta and tumour necrosis factor receptor 1 and 2 polymorphisms across the clinical spectrum of multiple sclerosis.Semantic proximity Read ↗

Tumor necrosis factor alpha-308 gene variants in relation to major histocompatibility complex alleles and Felty's syndrome.Semantic proximity Read ↗

Genetic variants in the tumor necrosis factor receptor II gene in patients with multiple sclerosis.Semantic proximity Read ↗

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