Loss of function and p53 protein stabilization.

doi:10.1038/sj.onc.1201374

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Article

Loss of function and p53 protein stabilization.

Oncogene - 16 Oct 1997

Blagosklonny M V

Abstract excerpt

Wild-type (wt) p53 protein is rapidly degraded, has a short half-life and low intracellular levels. Stabilization of wt p53 protein following an appropriate stimulus (for example DNA damage) is a physiological regulation to increase function. In contrast, stabilization of p53 protein in the absen...

Topics

Hydrolysis
Mutation
Protein Binding
Tumor Suppressor Protein p53

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