Article
Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2.
Nature - 26 Sept 1991
van Lohuizen M, Frasch M, Wientjens E, Berns A
Abstract excerpt
The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse protein Mel-18. Here we report on the cloning and characterization of a homologous gene (D-bmi)...
Topics
- Amino Acid Sequence
- Animals
- Drosophila melanogaster
- Genes, Regulator
- Mice
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Phenotype
- Proto-Oncogenes
- Sequence Homology, Nucleic Acid