Article
The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors.
Immunity - 1 Jul 1997
Akasaka T, Tsuji K, Kawahira H, Kanno M, Harigaya K, Hu L, Ebihara Y, Nakahata T, Tetsu O, Taniguchi M, Koseki H
Abstract excerpt
mel-18 is a mammalian homolog of Drosophila melanogaster Polycomb group genes. Mice lacking the mel-18 gene show a posterior transformation of the axial skeleton, severe combined immunodeficiency, and a food-passing disturbance in the lower intestine due to hypertrophy of the smooth muscle layer....
Topics
- Animals
- Bone Marrow Cells
- Cell Cycle
- Cell Division
- DNA-Binding Proteins
- Flow Cytometry
- Genotype
- Hematopoietic Stem Cells
- Interleukin-7
- Lymphocytes
- Mice
- Polycomb Repressive Complex 1
- Signal Transduction
- Zinc Fingers