CDC37 is required for p60v-src activity in yeast.

doi:10.1091/mbc.7.9.1405

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Article

CDC37 is required for p60v-src activity in yeast.

Molecular biology of the cell - 1 Sept 1996

Dey B, Lightbody J J, Boschelli F

Abstract excerpt

Mutations in genes encoding the molecular chaperones Hsp90 and Ydj1p suppress the toxicity of the protein tyrosine kinase p60v-src in yeast by reducing its levels or its kinase activity. We describe isolation and characterization of novel p60v-src-resistant, temperature-sensitive cdc37 mutants, c...

Topics

Cell Cycle Proteins
Drosophila Proteins
Enzyme Activation
G1 Phase
G2 Phase
Gene Expression Regulation, Fungal
Genes, Lethal
Genes, Suppressor
Mitosis
Molecular Chaperones
Mutation
Oncogene Protein pp60(v-src)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Sodium Dodecyl Sulfate

Solubility

Temperature

Tyrosine

Urea

Source

Open in PubMed Open full text

Identifiers

PMID: 8885235
DOI: 10.1091/mbc.7.9.1405
PMCID: PMC275990

Genes

CDC37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8885235-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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CDC37 is required for p60v-src activity in yeast.PMID 8885235Read ↗

The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability.Semantic proximity Read ↗

Cdc37 is a molecular chaperone with specific functions in signal transduction.Semantic proximity Read ↗

Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The lethality of p60v-src in Saccharomyces cerevisiae and the activation of p34CDC28 kinase are dependent on the integrity of the SH2 domain.Semantic proximity Read ↗

The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest.Semantic proximity Read ↗

Differential in vivo regulation of steroid hormone receptor activation by Cdc37p.Semantic proximity Read ↗

Loss of Hsp70-Hsp40 chaperone activity causes abnormal nuclear distribution and aberrant microtubule formation in M-phase of Saccharomyces cerevisiae.Semantic proximity Read ↗

Dissecting the Cdc37 cochaperone code: Functional roles in chaperone-mediated stress adaptation.Semantic proximity Read ↗

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.Semantic proximity Read ↗

Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.Semantic proximity Read ↗

Cdc37 promotes the stability of protein kinases Cdc28 and Cak1.Semantic proximity Read ↗

Cak1 is required for Kin28 phosphorylation and activation in vivo.Semantic proximity Read ↗

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