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Article

CDC37 is required for p60v-src activity in yeast.

Molecular biology of the cell - 1 Sept 1996

Dey B, Lightbody J J, Boschelli F

Abstract excerpt

Mutations in genes encoding the molecular chaperones Hsp90 and Ydj1p suppress the toxicity of the protein tyrosine kinase p60v-src in yeast by reducing its levels or its kinase activity. We describe isolation and characterization of novel p60v-src-resistant, temperature-sensitive cdc37 mutants, cdc37-34 and cdc37-17, which produce less p60v-src than the parental wild-type strain at 23 degrees C. However, p60v-src...

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Source

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Identifiers

PMID: 8885235
DOI: 10.1091/mbc.7.9.1405
PMCID: PMC275990

Genes

CDC37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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CDC37 is required for p60v-src activity in yeast.PMID 8885235Read ↗

The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability.Semantic proximity Read ↗

Cdc37 is a molecular chaperone with specific functions in signal transduction.Semantic proximity Read ↗

Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The lethality of p60v-src in Saccharomyces cerevisiae and the activation of p34CDC28 kinase are dependent on the integrity of the SH2 domain.Semantic proximity Read ↗

The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest.Semantic proximity Read ↗

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Loss of Hsp70-Hsp40 chaperone activity causes abnormal nuclear distribution and aberrant microtubule formation in M-phase of Saccharomyces cerevisiae.Semantic proximity Read ↗

Dissecting the Cdc37 cochaperone code: Functional roles in chaperone-mediated stress adaptation.Semantic proximity Read ↗

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.Semantic proximity Read ↗

Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.Semantic proximity Read ↗

Cdc37 promotes the stability of protein kinases Cdc28 and Cak1.Semantic proximity Read ↗

Cak1 is required for Kin28 phosphorylation and activation in vivo.Semantic proximity Read ↗

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