Article
Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.
Molecular biology of the cell - 1 Mar 1994
Florio M, Wilson L K, Trager J B, Thorner J, Martin G S
Abstract excerpt
Expression of pp60v-src, the transforming protein of Rous sarcoma virus, arrests the growth of the yeast Saccharomyces cerevisiae. To determine the basis of this growth arrest, yeast strains were constructed that expressed either wild-type v-src or various mutant v-src genes under the control of...
Topics
- Avian Sarcoma Viruses
- Cell Cycle
- Fungal Proteins
- Gene Expression
- Growth Inhibitors
- Humans
- Mutation
- Oncogene Protein pp60(v-src)
- Phosphorylation
- Protein Tyrosine Phosphatases
- Saccharomyces cerevisiae