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Article

Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Mar 1994

Florio M, Wilson L K, Trager J B, Thorner J, Martin G S

Abstract excerpt

Expression of pp60v-src, the transforming protein of Rous sarcoma virus, arrests the growth of the yeast Saccharomyces cerevisiae. To determine the basis of this growth arrest, yeast strains were constructed that expressed either wild-type v-src or various mutant v-src genes under the control of the galactose-inducible, glucose repressible GAL1 promoter. When shifted to galactose medium, cells expressing...

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Identifiers

PMID: 8049521
DOI: 10.1091/mbc.5.3.283
PMCID: PMC301037

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.PMID 8049521Read ↗

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Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.Semantic proximity Read ↗

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The amino-terminal region of pp60c-src has a modulatory role and contains multiple sites of tyrosine phosphorylation.Semantic proximity Read ↗

Host range mutants of v-src: alterations in kinase activity and substrate interactions.Semantic proximity Read ↗

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