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Article

Cak1 is required for Kin28 phosphorylation and activation in vivo.

Molecular and cellular biology - 1 Nov 1998

Espinoza F H, Farrell A, Nourse J L, Chamberlin H M, Gileadi O, Morgan D O

Abstract excerpt

Complete activation of most cyclin-dependent protein kinases (CDKs) requires phosphorylation by the CDK-activating kinase (CAK). In the budding yeast, Saccharomyces cerevisiae, the major CAK is a 44-kDa protein kinase known as Cak1. Cak1 is required for the phosphorylation and activation of Cdc28, a major CDK involved in cell cycle control. We addressed the possibility that Cak1 is also required for the...

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Identifiers

PMID: 9774652
DOI: 10.1128/MCB.18.11.6365
PMCID: PMC109222

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Cak1 is required for Kin28 phosphorylation and activation in vivo.PMID 9774652Read ↗

A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.Semantic proximity Read ↗

The Cak1p protein kinase is required at G1/S and G2/M in the budding yeast cell cycle.Semantic proximity Read ↗

Mutational analysis of Cak1p, an essential protein kinase that regulates cell cycle progression.Semantic proximity Read ↗

The kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ccl1, a cyclin associated with protein kinase Kin28, controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription.Semantic proximity Read ↗

Activating phosphorylation of the Saccharomyces cerevisiae cyclin-dependent kinase, cdc28p, precedes cyclin binding.Semantic proximity Read ↗

Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).Semantic proximity Read ↗

Activation of the Bur1-Bur2 cyclin-dependent kinase complex by Cak1.Semantic proximity Read ↗

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.Semantic proximity Read ↗

Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast.Semantic proximity Read ↗

Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1.Semantic proximity Read ↗

The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

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