Article
The lethality of p60v-src in Saccharomyces cerevisiae and the activation of p34CDC28 kinase are dependent on the integrity of the SH2 domain.
Journal of cell science - 1 Jun 1993
Boschelli F, Uptain S M, Lightbody J J
Abstract excerpt
The lethal effects of the expression of the oncogenic protein tyrosine kinase p60v-src in Saccharomyces cerevisiae are associated with a loss of cell cycle control at the G1/S and G2/M checkpoints. Results described here indicate that the ability of v-Src to kill yeast is dependent on the integri...
Topics
- CDC28 Protein Kinase, S cerevisiae
- Cell Cycle
- Enzyme Activation
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Oncogene Protein pp60(v-src)
- Phenotype
- Phosphoproteins
- Phosphorylation
- Phosphotyrosine
- Protamine Kinase
- Protein Processing, Post-Translational
- Protein Structure, Tertiary
- Protein-Tyrosine Kinases
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae
- Sequence Deletion
- Tyrosine