Discrimination of HLA-B27 alleles by group-specific amplification followed by solid-phase sequencing.

doi:10.1016/0198-8859(95)00147-6

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Article

Discrimination of HLA-B27 alleles by group-specific amplification followed by solid-phase sequencing.

Human immunology - 1 Feb 1996

Blasczyk R, Weber M, van Lessen A, Schwella N, Huhn D, Salama A

Abstract excerpt

HLA-B27 is known to be highly associated with ankylosing spondylitis. Until now, nine B27 subtypes have been sequenced and may contribute in different fashions to ankylosing spondylitis. Additionally, the divergent subtypes may be of clinical importance in bone marrow transplantation with alterna...

Topics

Alleles
Base Sequence
Epitopes
Gene Amplification
HLA-B27 Antigen
Humans
Molecular Sequence Data
Sequence Analysis, DNA

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