Article
Rapid detection of all HLA-B*27 alleles (B*2701-B*2725) by group-specific polymerase chain reaction.
Tissue antigens - 1 Jan 2004
Zino E, Di Terlizzi S, Carugo C, Baggi L, Galli A, Bonini C, Rossini S, Mazzi B, Fleischhauer K
Abstract excerpt
Human leucocyte antigen-B*27 is strongly associated with a number of rheumatic diseases, including ankylosing spondylitis and reactive arthritis. Targeted detection of the B*27 group by molecular methods is hampered by the extreme heterogeneity of the serological B*27 group. Here, we describe a simple, rapid sequence-specific primer-based method for detection of all 28 B*27 alleles defined to date. The method...
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