Article
Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis.
Iranian journal of allergy, asthma, and immunology - 1 Mar 2008
Nicknam Mohamad Hossein, Mahmoudi Mahdi, Amirzargar Ali Akbar, Ganjalikhani Hakemi Mazdak, Khosravi Farideh, Jamshidi Ahmad Reza, Amirkhani Aref, Ansaripour Bita, Pourpak Zahra, Moin Mostafa, Nikbin Behrooz
Abstract excerpt
The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS). The strength of the disease association with B27 varies markedly among racial and ethnic populations. It is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distribution. It is important...
Topics
- Adolescent
- Adult
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-B Antigens
- HLA-B27 Antigen
- Humans
- Iran
- Male
- Middle Aged
- Polymorphism, Genetic
- Spondylitis, Ankylosing