Remarkable polymorphism of HLA-B27: an ongoing saga.

doi:10.1007/s11926-010-0126-x

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Article

Remarkable polymorphism of HLA-B27: an ongoing saga.

Current rheumatology reports - 1 Oct 2010

Khan Muhammad Asim

Abstract excerpt

Histocompatibility antigen HLA-B27 is a normal gene that is distributed worldwide with variable prevalence and shows a remarkable association with ankylosing spondylitis and related spondyloarthropathies. The precise biological explanation for this remarkable association remains elusive. HLA-B27 represents a family of closely related proteins encoded by an ever-increasing number of alleles; there are 75 alleles...

Topics

Age of Onset
Alleles
Animals
Disease Models, Animal
Genetic Predisposition to Disease
HLA-B27 Antigen
History, 20th Century
Humans
Mice
Polymorphism, Genetic
Prevalence
Spondylarthropathies
Spondylitis, Ankylosing

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Open in PubMed

Identifiers

PMID: 20683684
DOI: 10.1007/s11926-010-0126-x

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