Article
Optimization of HLA-B*27 ALLELE Genotyping by PCR-SSP.
Clinics (Sao Paulo, Brazil) - 1 Jan 2020
Lara-Armi Fernanda Formaggi, Visentainer Jeane Eliete Laguila, Alves Hugo Vicentin, Rocha-Loures Marco Antônio, Neves Janisleya Silva Ferreira, Colli Cristiane Maria, Lima Neto Quirino Alves de, Moliterno Ricardo Alberto, Sell Ana Maria
Abstract excerpt
OBJECTIVES: HLA-B27 is strongly associated with ankylosing spondylitis (AS) and its presence helps to confirm AS diagnosis. Due to the high HLA polymorphism and the differentiated contribution of alleles and molecules encoded by them, HLA-B*27 allele identification is relevant in the clinical follow-up, diagnosis, and treatment of this spondyloarthropathy. Inexpensive genotyping techniques with high specificity...
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