HLA-B27 polymorphism and worldwide susceptibility to ankylosing spondylitis.

doi:10.1111/j.1399-0039.1997.tb02724.x

Article

HLA-B27 polymorphism and worldwide susceptibility to ankylosing spondylitis.

Tissue antigens - 1 Feb 1997

Gonzalez-Roces S, Alvarez M V, Gonzalez S, Dieye A, Makni H, Woodfield D G, Housan L, Konenkov V, Abbadi M C, Grunnet N, Coto E, López-Larrea C

Abstract excerpt

HLA-B27 is strongly associated to ankylosing spondylitis (AS) and represents a family of eleven B27 alleles (B*2701-11). Our aim was to analyze the distribution of B27 subtypes by PCR/SSOP and genomic sequencing in a large group of populations (n = 17). 711 B27-positive samples from Caucasoid, As...

Topics

Alleles
Disease Susceptibility
Global Health
HLA-B27 Antigen
Humans
Phylogeny
Polymorphism, Genetic
Population
Spondylitis, Ankylosing

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