Article
HLA-B27 polymorphism and worldwide susceptibility to ankylosing spondylitis.
Tissue antigens - 1 Feb 1997
Gonzalez-Roces S, Alvarez M V, Gonzalez S, Dieye A, Makni H, Woodfield D G, Housan L, Konenkov V, Abbadi M C, Grunnet N, Coto E, López-Larrea C
Abstract excerpt
HLA-B27 is strongly associated to ankylosing spondylitis (AS) and represents a family of eleven B27 alleles (B*2701-11). Our aim was to analyze the distribution of B27 subtypes by PCR/SSOP and genomic sequencing in a large group of populations (n = 17). 711 B27-positive samples from Caucasoid, Asian, African, Amerindian and Polynesian populations were selected to ascertain transracial gene mapping of the B27...
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