Article
TCR binding differs for a bacterial superantigen (SEE) and a viral superantigen (Mtv-9).
The Journal of experimental medicine - 1 Oct 1996
Liao L, Marinescu A, Molano A, Ciurli C, Sekaly R P, Fraser J D, Popowicz A, Posnett D N
Abstract excerpt
Both superantigens (SAG) and many anti-TCR monoclonal antibodies (mAb) have specificity for the V beta region of the TCR encoded by TCRBV genes. For instance the bacterial SAG staphylococcal enterotoxin E (SEE), the retroviral SAG MTV-9 and the mAb OT145 each react with human T cells expressing BV6S7. This BV gene encodes two common alleles. We found that SEE and the mAb preferentially activate T cells expressing...
Topics
- Alleles
- Amino Acid Sequence
- Binding Sites
- Calcium
- Enterotoxins
- Flow Cytometry
- Fluorescent Antibody Technique, Indirect
- Humans
- Lymphocyte Activation
- Models, Molecular
- Molecular Sequence Data
- Polymerase Chain Reaction
- Protein Binding