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Article

HLA Class II Polymorphisms Determine Responses to Bacterial Superantigens

1 Feb 2004

Abstract excerpt

The excessive immunological response triggered by microbial superantigens has been implicated in the etiology of a wide range of human diseases but has been most clearly defined for the staphylococcal and streptococcal toxic shock syndromes. Because MHC class II presentation of superantigens to T cells is not MHC-restricted, the possibility that HLA polymorphisms could influence superantigenicity, and thus...

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Identifiers

PMID: 14734754
DOI: 10.4049/jimmunol.172.3.1719

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Source receipt: pubmed, retrieved 7 Sept 2026.

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