Article
The TCR Vbeta signature of bacterial superantigens spreads with stimulus strength.
International immunology - 1 Oct 2006
Llewelyn Martin, Sriskandan Shiranee, Terrazzini Nadia, Cohen Jonathan, Altmann Daniel M
Abstract excerpt
Superantigens (Sags) induce large-scale stimulation of T lymphocytes by a mechanism distinct from conventional antigen presentation, involving direct MHC binding and stimulation of TCR families based on Vbeta gene usage. The specific Vbeta targets of a given Sag have, since the earliest studies in murine models, been considered a hallmark of that toxin. Bacterial Sags are implicated in the aetiology of a wide...
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