Clonal heterogeneity of superantigen reactivity in human V beta 6+ T cell clones. Limited contributions of V beta sequence polymorphisms.

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Article

Clonal heterogeneity of superantigen reactivity in human V beta 6+ T cell clones. Limited contributions of V beta sequence polymorphisms.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1992

Goronzy J J, Oppitz U, Weyand C M

Abstract excerpt

Superantigens encoded in the genome or released by bacteria have been identified as potent modulators of the murine immune system. High frequencies of mature or immature T cells are activated or intrathymically deleted when superantigens cross-link MHC class II molecules and the V beta element of...

Topics

Alleles
Amino Acid Sequence
Antigens, Bacterial
Base Sequence
Clone Cells
Endotoxins
HLA-DR Antigens
Humans
Lymphocyte Activation
Molecular Sequence Data
Polymorphism, Genetic
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 1530864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1530864-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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