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Article

A role for membrane IgD in the tolerance of pathological human rheumatoid factor B cells.

European journal of immunology - 1 Sept 2002

Soulas Pauline, Koenig-Marrony Severine, Julien Sylvie, Knapp Anne-Marie, Garaud Jean-Claude, Pasquali Jean-Louis, Martin Thierry

Abstract excerpt

Under non-autoimmune conditions, rheumatoid factor (RF) B cells coexist peacefully with their antigen (IgG), or can be transiently activated during secondary immune responses because they can present xenoantigens to specific T cells captured in immune complex form. Such a situation should lead to affinity maturation of RF B cells and potentially dangerous production of high-affinity RF. We used two lines of...

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Identifiers

PMID: 12207347
DOI: 10.1002/1521-4141(200209)32:9<2623::AID-IMMU2623>3.0.CO;2-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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