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Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic mice

1 Jul 1992

Abstract excerpt

Transgenic mice were generated that express both the H and L chain genes derived from a hybridoma secreting an IgG2a mAb specific for ds- and ssDNA. This hybridoma is derived from a lupus mouse and can accelerate nephritis in young NZB x NZW F1 female mice and induce clinical nephritis in BALB/c mice. Some transgenic B cells did not exhibit allelic exclusion; they expressed both transgene-derived IgG and...

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Identifiers

PMID: 1607661
DOI: 10.4049/jimmunol.149.1.350

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