Article
Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice.
The Journal of experimental medicine - 1 Feb 1995
Tighe H, Heaphy P, Baird S, Weigle W O, Carson D A
Abstract excerpt
The singular ability of immunoglobulin genes to hypermutate their variable regions, while permitting the generation of high-affinity antibodies against foreign antigens, poses a problem in terms of maintenance of immunological self-tolerance. Immunoglobulin gene hypermutation driven by a foreign antigen has the potential to generate antibodies that cross-react with self-components. Consequently, there must exist...
Topics
- Animals
- B-Lymphocytes
- Cell Death
- Clonal Anergy
- Humans
- Immunoglobulin G
- Immunoglobulin M
- Immunohistochemistry
- Kinetics
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic