The use of mouse models to study epigenetics.

Abstract excerpt

Much of what we know about the role of epigenetics in the determination of phenotype has come from studies of inbred mice. Some unusual expression patterns arising from endogenous and transgenic murine alleles, such as the Agouti coat color alleles, have allowed the study of variegation, variable expressivity, transgenerational epigenetic inheritance, parent-of-origin effects, and position effects. These...

Topics

• Alleles
• Animals
• Disease Models, Animal
• Epigenesis, Genetic
• Female
• Gene Silencing
• Genes, Recessive
• Genetic Techniques
• Genotype
• Green Fluorescent Proteins
• Homozygote
• Male