Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

30 Dec 2015

Abstract excerpt

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)9 genomic editing has revolutionized the generation of mutant animals by simplifying the creation of null alleles in virtually any organism. However, most current approaches with this method require zygote injection, making it difficult to assess the adult, tissue-specific functions of genes that are widely expressed or which cause...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to RNA and protein synthesis mechanisms
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26719419
DOI: 10.1073/pnas.1523918113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9PMID 26719419Read ↗

CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias.Semantic proximity Read ↗

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase.Semantic proximity Read ↗

Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in miceSemantic proximity Read ↗

Fast, multiplexable and highly efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9Semantic proximity Read ↗

Cardiac Applications of CRISPR/AAV-Mediated Precise Genome EditingSemantic proximity Read ↗

Genome Editing for the Understanding and Treatment of Inherited CardiomyopathiesSemantic proximity Read ↗

Genome Editing for the Understanding and Treatment of CardiomyopathiesSemantic proximity Read ↗

Application of CRISPR-Cas9 gene editing for congenital heart diseaseSemantic proximity Read ↗

Atrial-Specific Gene Delivery Using an Adeno-Associated Viral VectorSemantic proximity Read ↗

Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardiaSemantic proximity Read ↗

Genome Editing and Cardiac ArrhythmiasSemantic proximity Read ↗

A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.