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Article

Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy.

Science (New York, N.Y.) - 4 Oct 2013

Jiang Jianming, Wakimoto Hiroko, Seidman J G, Seidman Christine E

Abstract excerpt

Dominant mutations in sarcomere proteins such as the myosin heavy chains (MHC) are the leading genetic causes of human hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy. We found that expression of the HCM-causing cardiac MHC gene (Myh6) R403Q mutation in mice can be selectively silenced by an RNA interference (RNAi) cassette delivered by an adeno-associated virus vector. RNAi-transduced MHC(403/+)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24092743
DOI: 10.1126/science.1236921
PMCID: PMC4100553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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