Article
Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation.
FEBS letters - 9 Oct 2002
Xie Xiaodong, Chan Rebecca J, Yoder Mervin C
Abstract excerpt
Thrombopoietin (Tpo) and its receptor, c-mpl, are expressed in murine embryonic stem (ES) cells. ES cells are maintained in a pluripotent state by leukemia inhibitory factor (LIF) via activation of the Janus kinase (Jak)-STAT3 signaling pathway. Tpo, like LIF, activates STAT3. We report that Tpo increases the number of undifferentiated colonies derived from wild type or Shp-2 mutant (Shp-2(Delta46-110)) ES cells....
Topics
- Cell Differentiation
- Cells, Cultured
- DNA-Binding Proteins
- Embryo, Mammalian
- Embryo, Nonmammalian
- Growth Inhibitors
- Homozygote
- Interleukin-6
- Intracellular Signaling Peptides and Proteins
- Leukemia Inhibitory Factor
- Lymphokines
- Mutation
- Protein Tyrosine Phosphatase, Non-Receptor Type 11