Article
Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells.
The Journal of biological chemistry - 21 May 1999
Ward A C, Smith L, de Koning J P, van Aesch Y, Touw I P
Abstract excerpt
Granulocyte colony-stimulating factor (G-CSF) regulates neutrophil production through activation of its cognate receptor, the G-CSF-R. Previous studies with deletion mutants have shown that the membrane-proximal cytoplasmic domain of the receptor is sufficient for mitogenic signaling, whereas the membrane-distal domain is required for differentiation signaling. However, the function of the four cytoplasmic...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cell Survival
- Leukemia, Myeloid
- Mice
- Mutation
- Receptors, Granulocyte Colony-Stimulating Factor
- Tumor Cells, Cultured