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Article

The majority of 22 Dutch high-risk breast cancer families are due to either BRCA1 or BRCA2.

European journal of human genetics : EJHG - 1 Jan 1996

Peelen T, Cornelis R S, van Vliet M, Petrij-Bosch A, Cleton-Jansen A M, Meijers-Heijboer H, Klijn J G, Vasen H F, Cornelisse C J, Devilee P

Abstract excerpt

We have analyzed, by a combination of mutation and linkage analysis, the genetic basis of 22 breast cancer families in which at least 4 cases of either breast cancer diagnosed under the age of 60 or ovarian cancer had occurred. Chain-terminating mutations in BRCA1 were evidenced in 6 families, and posterior probabilities of > 0.90 of being linked to BRCA1 in 3. The breast versus ovarian cancer ratio in these 9...

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Source

Identifiers

PMID: 8875189
DOI: 10.1159/000472203

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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