Article
Penetrance of breast cancer, ovarian cancer and contralateral breast cancer in BRCA1 and BRCA2 families: high cancer incidence at older age.
Breast cancer research and treatment - 1 Dec 2010
van der Kolk Dorina M, de Bock Geertruida H, Leegte Beike K, Schaapveld Michael, Mourits Marian J E, de Vries Jakob, van der Hout Annemieke H, Oosterwijk Jan C
Abstract excerpt
Accurate estimations of lifetime risks of breast and ovarian cancer are crucial for counselling women from BRCA1/2 families. We therefore determined breast and ovarian cancer penetrance in BRCA1/2 mutation families in the northern Netherlands and compared them with the incidence of cancers in the general population in this region. We identified 1188 female mutation carriers and first-degree female relatives in...
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