Article
Variation in mutation spectrum partly explains regional differences in the breast cancer risk of female BRCA mutation carriers in the Netherlands.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2014
Vos Janet R, Teixeira Natalia, van der Kolk Dorina M, Mourits Marian J E, Rookus Matti A, van Leeuwen Flora E, Collée Margriet, van Asperen Christi J, Mensenkamp Arjen R, Ausems Margreet G E M, van Os Theo A M, Meijers-Heijboer Hanne E J, Gómez-Garcia Encarna B, Vasen Hans F, Brohet Richard M, van der Hout Annemarie H, Jansen Liesbeth, Oosterwijk Jan C, de Bock Geertruida H
Abstract excerpt
BACKGROUND: We aimed to quantify previously observed relatively high cancer risks in BRCA2 mutation carriers (BRCA2 carriers) older than 60 in the Northern Netherlands, and to analyze whether these could be explained by mutation spectrum or population background risk. METHODS: This consecutive cohort study included all known pathogenic BRCA1/2 carriers in the Northern Netherlands (N = 1,050). Carrier and general...
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