Article
The origin, by mutation, of high level resistance to ceftazidime and cefotaxime in a clinical isolate of Enterobacter cloacae.
Journal of chemotherapy (Florence, Italy) - 1 Aug 1996
Blahová J, Lesická-Hupková M, Králiková K, Krcméry V, Mikovicová A
Abstract excerpt
Although strains of Enterobacter sp. produce a chromosomal AmpC beta-lactamase, they have been, in general, susceptible to cefotaxime or ceftazidime. But now resistance to ceftazidime has increased in nosocomial Enterobacter strains, reaching the level of 40%. A chromosomal mutation in the amp op...
Topics
- Aztreonam
- Bacterial Proteins
- Cefotaxime
- Ceftazidime
- Cephalosporin Resistance
- Conjugation, Genetic
- Drug Resistance, Microbial
- Enterobacter cloacae
- Mutation
- Operon
- Selection, Genetic
- beta-Lactamases