Article
Chromosomal system for studying AmpC-mediated beta-lactam resistance mutation in Escherichia coli.
Antimicrobial agents and chemotherapy - 1 May 2002
Petrosino Joseph F, Pendleton Amanda R, Weiner Joel H, Rosenberg Susan M
Abstract excerpt
In some enterobacterial pathogens, but not in Escherichia coli, loss-of-function mutations in the ampD gene are a common route to beta-lactam antibiotic resistance. We constructed an assay system for studying mechanism(s) of enterobacterial ampD mutation using the well-developed genetics of E. coli. We integrated the Enterobacter ampRC genes into the E. coli chromosome. These cells acquire spontaneous...
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