Article
Gene mutations responsible for overexpression of AmpC beta-lactamase in some clinical isolates of Enterobacter cloacae.
Journal of clinical microbiology - 1 Jun 2005
Kaneko Kenichi, Okamoto Ryoichi, Nakano Ryuichi, Kawakami Sayoko, Inoue Matsuhisa
Abstract excerpt
AmpC regulatory genes in 21 ceftazidime-resistant clinical isolates of Enterobacter cloacae (MICs of > or = 16 microg/ml) were characterized. All isolates exhibited AmpC overproduction due to AmpD mutation. Additionally, we found two AmpR mutants among the isolates. This is the first report of chromosomal ampR mutation in clinical isolates of E. cloacae.
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Ceftazidime
- Cephalosporin Resistance
- Enterobacter cloacae
- Enterobacteriaceae Infections
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- N-Acetylmuramoyl-L-alanine Amidase