Article
Genetic control of beta-lactamase production in Enterobacter cloacae.
Reviews of infectious diseases - 1 Jan 2000
Korfmann G, Wiedemann B
Abstract excerpt
In Enterobacter cloacae, mutations in favor of overproduction of beta-lactamase--leading to resistance to third-generation cephalosporins--occur at frequencies of 10(-4)-10(-7). Cloning experiments reveal that at least three genes are involved in the regulation of chromosomal beta-lactamase expression. The structural gene, ampC, is located adjacent to the regulatory gene, ampR, coding for a protein that can serve...
Topics
- Cloning, Molecular
- Enterobacter
- Enterobacteriaceae
- Gene Expression Regulation
- Genes
- Genes, Bacterial
- Genes, Regulator
- Genetic Complementation Test
- Mutation
- beta-Lactamases