Article
An extended-spectrum AmpC-type beta-lactamase obtained by in vitro antibiotic selection.
FEMS microbiology letters - 1 Aug 1998
Morosini M I, Negri M C, Shoichet B, Baquero M R, Baquero F, Blázquez J
Abstract excerpt
A predictive approach was assayed to evaluate the possibility of mutant Amp-C beta-lactamase emergence with increased substrate spectrum (including new C-3' quaternary ammonium cephems). The ampC gene encoding the AmpC beta-lactamase from Enterobacter cloacae was cloned and expressed in an AmpC-d...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Cephalosporins
- Cloning, Molecular
- Enterobacter cloacae
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- Penicillins
- Phenotype
- beta-Lactam Resistance
- beta-Lactamases