Article
Single-well genotyping of diallelic sequence variations by a two-color ELISA-based oligonucleotide ligation assay.
Nucleic acids research - 1 Oct 1996
Tobe V O, Taylor S L, Nickerson D A
Abstract excerpt
Single nucleotide substitutions and unique insertions/deletions are the most common form of DNA sequence variation and disease-causing mutation in the human genome. Because of the biological and medical importance of these variations, a wide array of methods have been developed for their typing. We have applied an approach that combines the amplification of polymorphic regions by the polymerase chain reaction...
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